British Journal of Nutrition the Effects of a Dietary Excess of Leucine on the Synthesis of Nicotinamide Nucleotides in the Rat the Effects of a Dietary Excess of Leucine on the Synthesis of Nicotinamide Nucleotides in the Rat 3 22
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چکیده
Bahieldin I. Magboul and David A. Bender British Journal of Nutrition / Volume 49 / Issue 03 / May 1983, pp 321 329 DOI: 10.1079/BJN19830041, Published online: 09 March 2007 Link to this article: http://journals.cambridge.org/abstract_S0007114583000458 How to cite this article: Bahieldin I. Magboul and David A. Bender (1983). The effects of a dietary excess of leucine on the synthesis of nicotinamide nucleotides in the rat. British Journal of Nutrition,49, pp 321329 doi:10.1079/BJN19830041 Request Permissions : Click here
منابع مشابه
Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine.
In order to investigate the mechanism of the pellagragenic action of excess dietary leucine, rats were fed on diets providing a minimally-adequate amount of tryptophan, with no preformed niacin, with and without the addition of 15 g leucine/kg diet. This amount of leucine in the diet has been demonstrated previously to lead to depletion of blood and liver nicotinamide nucleotides. The metabolis...
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1. In order to test the suggestion that a dietary excess of leucine may be a precipitating factor in pellagra, rats were fed on diets that provided 15 g leucine/kg in excess of requirements for 7 weeks from weaning. This led to a significant reduction in the concentrations of nicotinamide nucleotides in liver and blood. The effect was only apparent when the diets provided less than a minimally ...
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1. Feeding rats on a low-tryptophan, niacin-free, high-leucine diet resulted in impaired synthesis from tryptophan of the nicotinamide nucleotide coenzymes, NAD and NADP, and N1-methyl nicotinamide in isolated hepatocytes, compared with cells from animals fed on a low-tryptophan, niacin-free control diet providing an appropriate amount of leucine. This was accompanied by reduced accumulation of...
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Disturbances in the tryptophan-niacin pathway seen in endemic pellagra among sorghum eaters have been ascribed to high dietary intake of leucine. Vitamin B, plays an important role in several steps of this pathway. Therefore, studies on possible metabolic interrelations between excess dietary leucine and vitamin B, were undertaken in normal healthy human subjects. The results indicated that vit...
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